Andrieieva Kateryna, WANG Xiao-peng, Andrieiev Yuriy, ZHANG Wen
（School of Electronics & Information Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China）
Abstract： To control drug effects by detecting temperature difference between biologically active point (BAP) and intact area of skin for treatment of mental illness, a device is developed for monitoring the temperature of BAP and the dose medication and its change in real time to increase effectiveness of treatment. Two electrodes by Foll R method are used and BAP is determined based on topographic anatomical reference points. The temperature values are measured by integral thermometers DS18B20. the received data are processed and temperature difference is calculated and displayed under the control of microcontroller Atmega32 . The obtained data confirm the correlation between the temperature difference indicators BAP C7, Gi4 and neurological scales assessing severity of mental illness. The experimetal results show that the temperature difference can be criteria for evaluating the effects of drugs, which is the basis for computer control systems of of medical process of mental patients.
Key words： differential thermometry; biologically active points (BAP); monitoring drug effects
CLD number： TP277.2 Document code： A
Article ID： 1674-8042（2016）01-0091-08 doi： 10.3969/j.issn.1674-8042.2016.01.017
References
［1］ Reznikov K M, Shiryaev O Y, Fedorov B A. Monitoring the action of psychotropic drugs in the treatment of schizophrenia. Human and Medicine, In: Proceedings of XVIII Russian National Congress, Moscow, Russia, 2001: 112.
［2］ Mustafin A M. The connection between the biologically active points of human skin and its psychological functions. Experiment Biology and Medicine, 2003, 19(2): 30-43.
［3］ Fedorov B A, Balashov D Y, Kozlov D V, et al. The device thermopuncture monitoring action of psychotropic drugs in depressive disorders. Biomedical Technology and Electronics, 2004, 10(5): 96-102.
［4］ Reznikov K M, Borisova E A, Zhuravlev D V, et al. The device registration biopotentials and temperature of biologically active points: Russion. patent, 134028 U1. 2013-11-10.
［5］ Lapteva V I, Borisova EA. Ability to control the effects of drugs. In: Proceedings of the VI Russian Scientific and Practical Conference, Kazan, Russia, 2012: 86-88.
［6］ Verner F A. Fundamentals of electroacupuncture. IMEDIS, Moskow, 2007: 178-201.
［7］ Baranov V N. The use of microcontrollers AVR: schemes, algorithms, programs. Moskow: Dodeka-XXI, 2004: 288-341.
［8］ Childs B H. Practical temperature measurement. Oxford: Oxford University Press, 2001.
［9］ Fedorov B A. Development and substantiation of application method for increasing the effectiveness treatment of depressive disorders amitriptylin and tsipramil based on thermopuncture monitoring. Voronezh: Voronezh University, 2002: 24-27.
［10］ Semyan A P. 500 schemes for radio amateurs, power supplies. Radio Amateur, 2005: 227-281.
［11］ Shpak Y A. Programming in C language for AVR and PIC microcontrollers. Moskow: MK-Press, 2006: 400-483.
［12］ Berenfus V Y, Berenfus K S, Gmyrya T P. Atlas of acupuncture points. Donetsk, 2006: 54-60.
［13］ Konopelko R G. Modern technologies of drug monitoring in the treatment of schizophrenia. In: Proceedings of I8 International Conference oh New Information Technologies in Medicine, Biology, Pharmacy and Ecology: Yalta, Crimea, Ukraine, 2001: 58-59.
［14］ Zhuravlev D V, Reznikov K M. Thermometry human’s biologically active points. Design Radioelectronic Devices and Systems, Voronezh, Russia, 2004: 205-209.
［15］ Fedorov B A. Features of termopuncture indicators in schizophrenic patients. Pressing questions of psychiatry, narcology and medical psychology, Voronezh, Russia, 2002: 130-133.
［16］ Reznikov K M. Possible mechanisms of biological and pharmacological action of the anolyte and catholyte. Applied Information Aspects of Medicine, 2008, 11(2): 72-82.
［17］ Nicholas J V, White D R. Traceable Temperatures. John Wiley & Sons, Chichester Ltd., 2001.
［18］ Mosolov S N. Scales psychometric evaluation symptoms of schizophrenia and the concept of positive and negative disorders. Moscow: Slovo, 2001: 238-241.
［19］ Brott T, Adams H P. Measurements of acute cerebral infraction: a clinical examination scale. PubMed, 2009, 20(7): 64-70.
［20］ Kochetov A G. The statistical treatment of medical data: methodical recommendations for residents and postgraduate medical education, scientific workers. Moscow: RKNPK, 2012: 374-396.
基于穴位点体温差别的药效监测系统设计
安迎春, 王小鹏, Andrieiev Yuriy, 张 雯
（兰州交通大学 电子与信息工程学院， 甘肃 兰州 730070）
摘 要: 设计了一种通过检测生物活性点与皮肤完整区域之间温度差来监测药物疗效并优化心理疾病治疗的系统。 该系统通过实时监控服药计量， 以及时调整药量， 从而提高治疗的有效性。 系统采用两电极Foll方法结合中该地形解剖参考点找到生物活性点， 通过DS18B20测量温度， 利用ATmega32单片机对温度进行处理并实时显示温度差， 进而通过温度差反应药效。 本文数据证实了温差指标BAP C7、 Gi4与评估心理疾病严重程度的神经尺度之间的相关性。 实验结果表明， 温度差指标能够作为衡量药效的标准， 通过监测温度差可以有效实现心理疾病药效的监测。
关键词: 差分测温； 生物活性点； 监测药效
引用格式： Andrieieva Kateryna, WANG Xiao-peng, Andrieiev Yuriy, et al. Design of pharmacodynamic monitoring system based on acupuncture differential thermometry. Journal of Measurement Science and Instrumentation, 2016, 7(1)： 91-98. ［doi： 10.3969／j.issn.1674-8042.2016.01.017］
[full text view]
